Sodium Methoxide → HCID 23678949、化合物

HRID 1646142ノート

反応式

HRID 1646142 の反応式
[CH3:1][O:2][C:3]1[CH:8]=[C:7]([O:9][CH3:10])[N:6]=[C:5]([O:11][CH:12]([C:16]([O:19][CH2:20][CH3:21])([CH3:18])[CH3:17])[C:13]([OH:15])=[O:14])[N:4]=1.C[O-].[Na+:24]>CO>[CH3:10][O:9][C:7]1[CH:8]=[C:3]([O:2][CH3:1])[N:4]=[C:5]([O:11][CH:12]([C:16]([O:19][CH2:20][CH3:21])([CH3:17])[CH3:18])[C:13]([O-:15])=[O:14])[N:6]=1.[Na+:24]

参加物

4

反応物 2

HCID 10942334Sodium MethoxideHCID 157671522-((4,6-Dimethoxypyrimidin-2-yl)oxy)-3-ethoxy-3-methylbutanoic acid

生成物 1

HCID 23678949HCID 23678949、化合物収率 99.3%

試薬・触媒・溶媒 1

HCID 887Methanol溶媒

実験手順

To Compound 52 (30.0 g, 0.1 mol) prepared in the above (2) dissolved in methanol (100 ml) was added sodium methoxide (19.3 g, 28% methanol solution), and the mixture was stirred for 10 minutes. Subsequently, methanol was removed under reduced pressure to obtain 32 g of the title compound as white crystals.

後処理

  1. customSubsequently, methanol was removed under reduced pressure

出典と根拠

ORDレコード
ord-0f35a6820bf24157b3cc4cc1e8caa4e4
出典データセット
uspto-grants-1993_01
特許番号
US05178663

反応ノート

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