Hydrochloric Acid → 6-Chloro-N-(1H-indol-1-yl)-4-pyrimidinamine
反応式
C(O)(C)C.Cl[C:6]1[CH:11]=[C:10]([Cl:12])[N:9]=[CH:8][N:7]=1.Cl.[N:14]1([NH2:23])[C:22]2[C:17](=[CH:18][CH:19]=[CH:20][CH:21]=2)[CH:16]=[CH:15]1>O>[Cl:12][C:10]1[N:9]=[CH:8][N:7]=[C:6]([NH:23][N:14]2[C:22]3[C:17](=[CH:18][CH:19]=[CH:20][CH:21]=3)[CH:16]=[CH:15]2)[CH:11]=1参加物
6
反応条件
- 温度
- 90 °C
実験手順
To 250 ml isopropanol, was added 4,6-dichloropyrimidine (12 g), 1 ml ethereal -HCl, and 1H-indol-1-amine (15 g). After stirring at 90° C. for seven hours, the mixture was poured into 300 ml iced water, stirred for five minutes, then extracted three times with 200 ml of ethyl acetate. The organic layer was washed with water, then dried (saturated NaCl, anhydrous MgSO4).
後処理
- stirringstirred for five minutes
- extractionextracted three times with 200 ml of ethyl acetate
- washThe organic layer was washed with water
- dry with materialdried (saturated NaCl, anhydrous MgSO4)
出典と根拠
- ORDレコード
- ord-91aaf4bd026f4472a69dc07252e8f39d
- 出典データセット
- uspto-grants-1993_01
- 特許番号
- US05179204
反応ノート
読み込み中…