Acetic Anhydride → HCID 13298921、化合物

HRID 1646421ノート

反応式

HRID 1646421 の反応式
[CH3:1][C:2]1[CH:3]=[C:4]2[C:9](=[C:10]([CH2:13][CH:14]=[CH2:15])[C:11]=1[OH:12])[O:8][C:7](=[O:16])[CH:6]=[CH:5]2.[C:17](O[Na])([CH3:19])=[O:18].C(OC(=O)C)(=O)C>O>[CH3:1][C:2]1[CH:3]=[C:4]2[C:9](=[C:10]([CH2:13][CH:14]=[CH2:15])[C:11]=1[O:12][C:17](=[O:18])[CH3:19])[O:8][C:7](=[O:16])[CH:6]=[CH:5]2

参加物

5

反応物 3

HCID 7918Acetic AnhydrideHCID 13298918HCID 13298918、化合物HCID 178418247HCID 178418247、化合物

生成物 1

HCID 13298921HCID 13298921、化合物収率 129.2%

試薬・触媒・溶媒 1

HCID 962Water溶媒2 回

実験手順

In such a manner a mixture of 6-methyl-7-hydroxy-8-allylcoumarin (VII) (6.3 g), anhydrous AcONa (1.5 g) and acetic anhydride (40 ml) was refluxed for 1 h. The reaction mixture was gently diluted with water (40 ml), refluxed for 10 min and then poured into H2O (300 ml) yielding a precipitate, which was collected by filtration and washed several times with H2O. The dried product was crystallized from MeOH yielding 6-methyl-7-acetoxy-8-allylcoumarin (X) (6.1 g; m.p. 110°-11° C.). ##STR15##

後処理

  1. temperaturewas refluxed for 1 h
  2. temperaturerefluxed for 10 min
  3. customyielding a precipitate, which
  4. filtrationwas collected by filtration
  5. washwashed several times with H2O
  6. customThe dried product was crystallized from MeOH

出典と根拠

ORDレコード
ord-1e4fe41bfce74b06983c9687fc415827
出典データセット
uspto-grants-1993_01
特許番号
US05179217

反応ノート

読み込み中…