4-Acetyl-3-hydroxy-2-propylbenzyl chloride → 4'-[[(5-Amino-1,2,4-triazol-3-yl]thio]methyl]-2'-hydroxy-3'-propylacetophenone

HRID 1646517ノート

反応式

HRID 1646517 の反応式
[C:1]([C:4]1[CH:11]=[CH:10][C:7]([CH2:8]Cl)=[C:6]([CH2:12][CH2:13][CH3:14])[C:5]=1[OH:15])(=[O:3])[CH3:2].[NH2:16][C:17]1[N:21]=[C:20]([SH:22])[NH:19][N:18]=1>>[NH2:16][C:17]1[NH:18][N:19]=[C:20]([S:22][CH2:8][C:7]2[CH:10]=[CH:11][C:4]([C:1](=[O:3])[CH3:2])=[C:5]([OH:15])[C:6]=2[CH2:12][CH2:13][CH3:14])[N:21]=1

参加物

3

反応物 2

HCID 137810224-Acetyl-3-hydroxy-2-propylbenzyl chlorideHCID 1785092965-amino-1H-1,2,4-triazole-3-thiol

生成物 1

HCID 143730034'-[[(5-Amino-1,2,4-triazol-3-yl]thio]methyl]-2'-hydroxy-3'-propylacetophenone収率 61.7%

実験手順

Using 0.30 g of 4-acetyl-3-hydroxy-2-propylbenzyl chloride and 0.18 g of 3-amino-5-mercapto-1,2,4-triazole as starting materials, 0.25 g of 4'-[[(5-amino-1,2,4-triazol-3-yl]thio]methyl]-2'-hydroxy -3'-propylacetophenone was obtained in a manner similar to Example 25.

出典と根拠

ORDレコード
ord-389c03d94b064692930cd948972ae1ca
出典データセット
uspto-grants-1993_01
特許番号
US05180730

反応ノート

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