1,3-Propanedithiol → 2-Fluoroadenine

HRID 1646670

反応式

HRID 1646670 の反応式
C(N(CC)CC)C.[N:8]([C:11]1[N:19]=[C:18]([F:20])[N:17]=[C:16]2[C:12]=1[NH:13][CH:14]=[N:15]2)=[N+]=[N-].C(S)CCS>CO>[F:20][C:18]1[N:17]=[C:16]2[C:12]([NH:13][CH:14]=[N:15]2)=[C:11]([NH2:8])[N:19]=1

参加物

5

反応物 3

HCID 80131,3-PropanedithiolHCID 8471TriethylamineHCID 198012676-azido-2-fluoro-7H-purine

生成物 1

HCID 127902-Fluoroadenine収率 92.8%

試薬・触媒・溶媒 1

HCID 887Methanol溶媒

実験手順

Triethylamine (0.40 mL) was added via syringe to a solution of 6-azido-2-fluoropurine (0.256 g) and 1,3-propanedithiol (0.29 mL) in methanol (13.5 mL). After 15 minutes the reaction was complete as judged by TLC and a white precipitate had formed. The precipitate was collected by filtration and washed with two 10 mL portions of methanol and then dried to obtain 0.203 g of 2-fluoroadenine, mp>300° C. This material was identical to an authentic sample by TLC, NMR and IR.

後処理

  1. customa white precipitate had formed
  2. filtrationThe precipitate was collected by filtration
  3. washwashed with two 10 mL portions of methanol
  4. customdried

出典と根拠

ORDレコード
ord-d089e88f144d47ecba88e636713cf25d
出典データセット
uspto-grants-1993_01
特許番号
US05180824

関連ノート

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