1,3-Propanedithiol → 2-Fluoroadenine
反応式
C(N(CC)CC)C.[N:8]([C:11]1[N:19]=[C:18]([F:20])[N:17]=[C:16]2[C:12]=1[NH:13][CH:14]=[N:15]2)=[N+]=[N-].C(S)CCS>CO>[F:20][C:18]1[N:17]=[C:16]2[C:12]([NH:13][CH:14]=[N:15]2)=[C:11]([NH2:8])[N:19]=1参加物
5
実験手順
Triethylamine (0.40 mL) was added via syringe to a solution of 6-azido-2-fluoropurine (0.256 g) and 1,3-propanedithiol (0.29 mL) in methanol (13.5 mL). After 15 minutes the reaction was complete as judged by TLC and a white precipitate had formed. The precipitate was collected by filtration and washed with two 10 mL portions of methanol and then dried to obtain 0.203 g of 2-fluoroadenine, mp>300° C. This material was identical to an authentic sample by TLC, NMR and IR.
後処理
- customa white precipitate had formed
- filtrationThe precipitate was collected by filtration
- washwashed with two 10 mL portions of methanol
- customdried
出典と根拠
- ORDレコード
- ord-d089e88f144d47ecba88e636713cf25d
- 出典データセット
- uspto-grants-1993_01
- 特許番号
- US05180824
反応ノート
読み込み中…