Water → HCID 14209239、化合物

HRID 1646857ノート

反応式

HRID 1646857 の反応式
[Br:1][C:2]1[CH:3]=[N:4][C:5]2[C:10]([C:11]=1Cl)=[CH:9][CH:8]=[CH:7][CH:6]=2.[OH2:13]>>[Br:1][C:2]1[CH:3]=[N:4][C:5]2[C:10]([C:11]=1[NH:4][CH2:3][CH:2]([OH:13])[CH3:11])=[CH:9][CH:8]=[CH:7][CH:6]=2

参加物

3

反応物 2

HCID 962WaterHCID 6183063-Bromo-4-chloroquinoline

生成物 1

HCID 14209239HCID 14209239、化合物

反応条件

温度
150 °C

実験手順

A mixture of 3 g of 3-bromo-4-chloro-quinoline and 10 g of aminopropanol-2 was heated to 150° C. for 20 minutes. The mixture was cooled and poured into 120 ml of water and the product was extracted with 100 ml of ether. The ether layer was dried over sodium sulfate, the solvent removed by evaporation and the residue recrystallized from ether/hexane. The yield was 2.6 g, mp 82°-83° C.

後処理

  1. temperatureThe mixture was cooled
  2. extractionthe product was extracted with 100 ml of ether
  3. dry with materialThe ether layer was dried over sodium sulfate
  4. customthe solvent removed by evaporation
  5. customthe residue recrystallized from ether/hexane

出典と根拠

ORDレコード
ord-660266b9542845be9f2fdabbdbeeeb72
出典データセット
uspto-grants-1993_01
特許番号
US05182275

反応ノート

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