Water → HCID 14836359、化合物

HRID 1646868ノート

反応式

HRID 1646868 の反応式
CC(C)([O-])C.[K+].Br[C:8]1[CH:9]=[N:10][C:11]2[C:16]([C:17]=1[NH:18][CH2:19][CH:20]([OH:22])[CH3:21])=[CH:15][CH:14]=[CH:13][CH:12]=2.O>CN(C=O)C>[CH3:21][CH:20]1[O:22][C:8]2[CH:9]=[N:10][C:11]3[CH:12]=[CH:13][CH:14]=[CH:15][C:16]=3[C:17]=2[NH:18][CH2:19]1

参加物

5

反応物 3

HCID 962WaterHCID 14209239HCID 14209239、化合物HCID 23665647Potassium tert-butoxide

生成物 1

HCID 14836359HCID 14836359、化合物

試薬・触媒・溶媒 1

HCID 6228Dimethylformamide溶媒

反応条件

温度
140 °C

実験手順

Potassium tertiary butoxide (5 g) was added to a solution of 3-bromo-N-(2-hydroxypropyl)-4-quinolinamine (9 g) in 30 ml of DMF and the mixture stirred at 140° C. for 4 hours. The mixture was cooled to room temperature and poured into 200 ml of water. The product was extracted with dichloromethane and purified by HPLC (solvent: DCM:MeOH=10:1).

後処理

  1. temperatureThe mixture was cooled to room temperature
  2. extractionThe product was extracted with dichloromethane
  3. custompurified by HPLC (solvent: DCM:MeOH=10:1)

出典と根拠

ORDレコード
ord-26df10b226144ed1874a56b2af1e8de8
出典データセット
uspto-grants-1993_01
特許番号
US05182275

反応ノート

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