4-Cyclopropylmethoxy-3-methoxy-2-chloromethyl pyridine hydrochloride → 5-Carbomethoxy-6-methyl-2-[[(4-cyclopropylmethoxy-3-methoxy-2-pyridinyl)methyl]thio]-1H-benzimidazole
反応式
[C:1]([C:5]1[C:14]([CH3:15])=[CH:13][C:8]2[NH:9][C:10]([SH:12])=[N:11][C:7]=2[CH:6]=1)([O:3][CH3:4])=[O:2].Cl.[CH:17]1([CH2:20][O:21][C:22]2[CH:27]=[CH:26][N:25]=[C:24]([CH2:28]Cl)[C:23]=2[O:30][CH3:31])[CH2:19][CH2:18]1>CO>[C:1]([C:5]1[C:14]([CH3:15])=[CH:13][C:8]2[NH:9][C:10]([S:12][CH2:28][C:24]3[C:23]([O:30][CH3:31])=[C:22]([O:21][CH2:20][CH:17]4[CH2:19][CH2:18]4)[CH:27]=[CH:26][N:25]=3)=[N:11][C:7]=2[CH:6]=1)([O:3][CH3:4])=[O:2]参加物
4
実験手順
To a solution of 5-carbomethoxy-6-methyl-2-mercapto-1H-benzimidazole (0.58 g, 2.6 mmol) in methanol (25 ml) aqueous NaOH (1.0 ml 5M, 5.0 mmol) and 4-cyclopropylmethoxy-3-methoxy-2-chloromethyl pyridine hydrochloride (prepared according to processes known per se.) (0.63 g, 2.4 mmol) dissolved in methanol (25 ml were added in the given order. The mixture was refluxed for one hour whereupon the solution was evaporated. The residue was partitioned between methylene chloride and water. After separation the organic solution was dried over Na2SO4 and evaporated giving a yellow syrup (1.0 g, 100%).