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Triethylamine → [1-[[(1H-Benzimidazol-2-ylmethyl)amino]carbonyl]-2-methylbutyl]carbamic acid 1,1-dimethylethyl ester
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Triethylamine | HCID 8471 | — |
| 反応物 | Benzimidazol-2-ylmethylamine dihydrochloride hydrate | HCID 145819 | — |
| 反応物 | Benzotriazol-1-yloxy-tris(dimethylamino)phosphonium hexafluorophosphate | HCID 151348 | — |
| 反応物 | tert-Butoxycarbonyl-L-isoleucine | HCID 2724762 | — |
| 溶媒 | Dichloromethane | HCID 6344 | — |
| 生成物 | [1-[[(1H-Benzimidazol-2-ylmethyl)amino]carbonyl]-2-methylbutyl]carbamic acid 1,1-dimethylethyl ester | HCID 67747066 | 88.4% |
反応手順
The title compound is prepared by the procedure of Example 1 using 0.505 g of N-(tert-butoxycarbonyl)-L-isoleucine in 10 ml of methylene chloride, 0.500 g of 2-(aminomethyl)benzimidazole dihydrochloride hydrate, 1.07 g of BOP, and 0,850 g of triethylamine. Purification by chromatography (75 g Silica gel; 70% ethyl acetate/hexane) gives 0.669 g of the desired product.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US05430150 |
| 出典データセット | uspto-grants-1995_07 |
| ORD ID | ord-7096213deeb64948bdecfd6cbc428085 |
| 出典メモ | uspto-grants-1995_07 |