関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | Hydrogen Bromide | HCID 260 | — |
| 反応物 | D-Phenylalanine | HCID 71567 | — |
| 反応物 | Sodium Nitrite | HCID 23668193 | — |
| 溶媒 | Water | HCID 962 | — |
| 生成物 | (R)-2-Bromo-3-phenylpropionic acid | HCID 11746403 | 43% |
反応手順
Mix D-phenylalanine (186.4g, 1.128mol) and 49% hydrobromic acid (372.8g), cool to -5° C. and add, by dropwise addition, a solution of sodium nitrite (77.9g) in water (565mL) over a period of about 1 hour (vigorous gas evolution). Stir at -5° C. to 0° C. for 4 hours, extract into ethyl ether (3×1L), dry (MgSO4) and evaporate the solvent in vacuo. Purify by chromatography (5% acetic aci/95% methylene chloride) and distillation to give 3-phenyl-2(R)-bromopropionic acid (112g, 43%); bp 128°-135° C. @0.25 torr.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 特許番号 | US05430145 |
|---|
| 出典データセット | uspto-grants-1995_07 |
|---|
| ORD ID | ord-4ba112e7390d4c33b5fc407d5ff480b4 |
|---|
| 出典メモ | uspto-grants-1995_07 |
|---|
