Triethylamine → Dimethylaminopropyl thiohydantoin valine

HRID 1647383

反応式

HRID 1647383 の反応式
C([O:3][C:4](=[O:10])[C@H:5]([CH:7]([CH3:9])[CH3:8])[NH2:6])C.[CH3:11][N:12]([CH2:14][CH2:15][CH2:16][N:17]=[C:18]=[S:19])[CH3:13].[CH2:20]([N:22](CC)CC)[CH3:21]>CO>[NH2:6][C@H:5]([C:4]([OH:10])=[O:3])[CH:7]([CH3:9])[CH3:8].[CH3:11][N:12]([CH2:14][CH2:15][CH2:16][N:17]1[CH2:21][C:20](=[O:3])[NH:22][C:18]1=[S:19])[CH3:13]

参加物

5

反応物 3

HCID 8471TriethylamineHCID 87182l-Valine, ethyl esterHCID 1413513-((Dimethylamino)phenyl isothiocyanate

生成物 1

HCID 86748773Dimethylaminopropyl thiohydantoin valine

試薬・触媒・溶媒 1

HCID 887Methanol溶媒

実験手順

Valine ethyl ester (0.01 mol) in 30 ml of anhydrous methanol was reacted with dimethylaminopropyl isothiocyanate (0.01 mol) for 3 hours at 50° C. The solution was made basic by the addition of two equivalents of triethylamine. Solvent was removed by rotary evaporation. Water was added to the solid residue and the residue was filtered and washed with water. The residue was dissolved in methanol and analyzed by FAB/MS. The expected product, dimethylaminopropyl thiohydantoin valine (MH+=244), was obtained.

後処理

  1. customSolvent was removed by rotary evaporation
  2. additionWater was added to the solid residue
  3. filtrationthe residue was filtered
  4. washwashed with water
  5. dissolutionThe residue was dissolved in methanol

出典と根拠

ORDレコード
ord-433c315089c44813a8711837dd95fa0e
出典データセット
uspto-grants-1995_07
特許番号
US05432093

関連ノート

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