Boron tribromide → HCID 10263493、化合物
反応式
[C:1]([C:5]1[CH:6]=[N:7][C:8]2[C:13]([C:14]=1[Cl:15])=[CH:12][CH:11]=[CH:10][C:9]=2[O:16]C)(=[O:4])[CH2:2][CH3:3].B(Br)(Br)Br>ClCCl>[C:1]([C:5]1[CH:6]=[N:7][C:8]2[C:13]([C:14]=1[Cl:15])=[CH:12][CH:11]=[CH:10][C:9]=2[OH:16])(=[O:4])[CH2:2][CH3:3]参加物
4
実験手順
3-Propanoyl-4-chloro-8-methoxyquinoline (32 g) was dissolved in dichloromethane (250 ml), cooled to -78°, and boron tribromide (37 ml) added slowly. The solution was allowed to warm slowly to room temperature overnight, then recooled in ice and quenched cautiously with water. The resulting solid was filtered off and washed with water to give crude 3-propanoyl-4-chloro-8-hydroxyquinoline (115 g crude weight), which was used without further purification.
後処理
- temperaturecooled to -78°
- customquenched cautiously with water
- filtrationThe resulting solid was filtered off
- washwashed with water
出典と根拠
- ORDレコード
- ord-1198ecbcc966492abd66e3aac1c2d6bb
- 出典データセット
- uspto-grants-1995_07
- 特許番号
- US05432182
反応ノート
読み込み中…