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HRID 1647553作成日：2026年10月25日

2-(2-Chlorophenyl)-4-(piperidin-1-yl)butanenitrile → alpha-(2-Chlorophenyl)-alpha-[2-[(1-methylethyl) (phenylmethyl)amino]ethyl]-1-piperidine butanenitrile

https://huagongshe.com/reaction/1647553

反応式

関与物質

役割名称HCID仕込み量
反応物2-(2-Chlorophenyl)-4-(piperidin-1-yl)butanenitrileHCID 11043596—
反応物N-(2-chloroethyl)-N-(1-methylethyl)benzenemethanamine, monohydrochlorideHCID 24185321—
溶媒Dimethyl SulfoxideHCID 679—
生成物alpha-(2-Chlorophenyl)-alpha-[2-[(1-methylethyl) (phenylmethyl)amino]ethyl]-1-piperidine butanenitrileHCID 11112943—

反応手順

alkylating α-(2-chlorophenyl)-1-piperidinebutanenitrile with N-(2-chloroethyl)-N-(1-methylethyl)benzenemethanamine, monohydrochloride in the presence of base and dimethyl sulfoxide to give α-(2-chlorophenyl)-α-[2-[(1-methylethyl) (phenylmethyl)amino]ethyl]-1-piperidine butanenitrile;

情報源と証拠

DOI10.6084/m9.figshare.5104873.v1
特許番号US05432284
出典データセットuspto-grants-1995_07
ORD IDord-1d428c985a944d9cb615b9fcf74326d0
出典メモuspto-grants-1995_07