1-Naphthalenamine, 5-nitro- → 1-(1-Azabicyclo[3.3.0]octan-5-yl)methylamino-5-nitronaphthalene

反応式

[NH2:1][C:2]1[C:11]2[C:6](=[C:7]([N+:12]([O-:14])=[O:13])[CH:8]=[CH:9][CH:10]=2)[CH:5]=[CH:4][CH:3]=1.Cl[CH2:16][C:17]12[CH2:24][CH2:23][CH2:22][N:21]1[CH2:20][CH2:19][CH2:18]2>>[N:21]12[CH2:22][CH2:23][CH2:24][C:17]1([CH2:16][NH:1][C:2]1[C:11]3[C:6](=[C:7]([N+:12]([O-:14])=[O:13])[CH:8]=[CH:9][CH:10]=3)[CH:5]=[CH:4][CH:3]=1)[CH2:18][CH2:19][CH2:20]2

参加物

反応物 2

HCID 767591-Naphthalenamine, 5-nitro-

HCID 107732517a-(chloromethyl)-hexahydro-1H-pyrrolizine

生成物 1

HCID 107813461-(1-Azabicyclo[3.3.0]octan-5-yl)methylamino-5-nitronaphthalene収率 45.3%

実験手順

1-Amino-5-nitronaphthalene and 5-chloromethyl-1-azabicyclo[3.3.0]octane were reacted in the same manner as in Example 3 to obtain the titled compound in a yield of 45.3%.

出典と根拠

ORDレコード: ord-e4012ac3bcc345caa3a3ce98116a66dc
出典データセット: uspto-grants-1995_07
DOI: 10.6084/m9.figshare.5104873.v1
特許番号: US05434165

反応ノート

読み込み中…