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Sodium Carbonate → 2-(1-Amidino-4-piperidinyl)-5-[(2-methoxycarbonyl-ethyl)-aminocarbonyl]-1-methyl-benzimidazole
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Sodium Carbonate | HCID 10340 | — |
| 反応物 | S-Ethylisothiuronium bromide | HCID 200213 | — |
| 反応物 | 5-[(2-Methoxycarbonyl-ethyl)-aminocarbonyl]-1-methyl-2-(4-piperidinyl)-benzimidazole | HCID 19921265 | — |
| 溶媒 | Dimethylformamide | HCID 6228 | — |
| 生成物 | 2-(1-Amidino-4-piperidinyl)-5-[(2-methoxycarbonyl-ethyl)-aminocarbonyl]-1-methyl-benzimidazole | HCID 19921162 | — |
反応手順
Prepared from 5-[(2-methoxycarbonyl-ethyl)-aminocarbonyl]-1-methyl-2-(4-piperidinyl)-benzimidazole and S-ethylisothiourea-hydrobromide by heating to 100° C. for 4 hours in dimethylformamide in the presence of sodium carbonate.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US05434150 |
| 出典データセット | uspto-grants-1995_07 |
| ORD ID | ord-3203693e9a7b471988dc7a71f97095a1 |
| 出典メモ | uspto-grants-1995_07 |