Glycine → O-methoxymethyl-beta-hydroxytyrosine

HRID 1648174ノート

反応式

HRID 1648174 の反応式
[OH-].[K+].[NH2:3][CH2:4][C:5]([OH:7])=[O:6].[CH3:8][O:9][CH2:10][O:11][C:12]1[CH:19]=[CH:18][C:15]([CH:16]=[O:17])=[CH:14][CH:13]=1>C(O)C>[CH3:8][O:9][CH2:10][O:11][C:12]1[CH:19]=[CH:18][C:15]([CH:16]([OH:17])[C@@H:4]([C:5]([OH:7])=[O:6])[NH2:3])=[CH:14][CH:13]=1

参加物

5

反応物 3

HCID 750GlycineHCID 14797Potassium HydroxideHCID 2500744-(Methoxymethoxy)benzaldehyde

生成物 1

HCID 54167947O-methoxymethyl-beta-hydroxytyrosine収率 19.6%

試薬・触媒・溶媒 1

HCID 702Ethanol溶媒

実験手順

To a solution of potassium hydroxide (26.8 g) in ethanol (500 ml) was added glycine (14.6 g) and 4-methoxymethoxybenzaldehyde (48.5 g) at room temperature. After stirring for 19 hours, the solvent was removed in vacuo. The residue was dissolved in water and acidified with hydrochloric acid. The solution was washed with ethyl acetate and adjusted to pH 6.0 with sodium bicarbonate. White solid was precipitated and collected to give O-methoxymethyl-β-hydroxytyrosine (9.2 g).

後処理

  1. customthe solvent was removed in vacuo
  2. dissolutionThe residue was dissolved in water
  3. washThe solution was washed with ethyl acetate
  4. customWhite solid was precipitated
  5. customcollected

出典と根拠

ORDレコード
ord-cde470487215418c8df1b92e55c6603a
出典データセット
uspto-grants-1995_07
特許番号
US05436140

反応ノート

読み込み中…