N-methylene-1-methyl-1-(3-chlorophenyl)ethylamine → 5-isobutyl-6-methyl-3-[1-methyl-1-(3-chlorophenyl)ethyl]-2,3-dihydro-4H-1,3-oxazin-4-one

HRID 1648194ノート

反応式

HRID 1648194 の反応式
[CH2:1]([C:5]1[C:6](=[O:14])O[C:8](C)(C)[O:9][C:10]=1[CH3:11])[CH:2]([CH3:4])[CH3:3].C=[N:16][C:17]([CH3:26])([C:19]1[CH:24]=[CH:23][CH:22]=[C:21]([Cl:25])[CH:20]=1)[CH3:18]>C1(C)C(C)=CC=CC=1>[CH2:1]([C:5]1[C:6](=[O:14])[N:16]([C:17]([CH3:26])([C:19]2[CH:24]=[CH:23][CH:22]=[C:21]([Cl:25])[CH:20]=2)[CH3:18])[CH2:8][O:9][C:10]=1[CH3:11])[CH:2]([CH3:3])[CH3:4]

参加物

4

反応物 2

HCID 15300847N-methylene-1-methyl-1-(3-chlorophenyl)ethylamineHCID 199189545-isobutyl-2,2,6-trimethyl-2H,4H-1,3-dioxin-4-one

生成物 1

HCID 199189625-isobutyl-6-methyl-3-[1-methyl-1-(3-chlorophenyl)ethyl]-2,3-dihydro-4H-1,3-oxazin-4-one収率 54.3%

試薬・触媒・溶媒 1

HCID 7237O-Xylene溶媒

実験手順

Xylene (1 ml) was added to a mixture of 5-isobutyl-2,2,6-trimethyl-2H,4H-1,3-dioxin-4-one (0.59 g) and N-methylene-1-methyl-1-(3-chlorophenyl)ethylamine (0.55 g), and the resulting mixture was heated at reflux for 60 minutes for reaction. The reaction mixture was purified by silica gel chromatography to obtain the captioned compound (0.52 g).

後処理

  1. temperaturethe resulting mixture was heated
  2. temperatureat reflux for 60 minutes for reaction
  3. customThe reaction mixture was purified by silica gel chromatography

出典と根拠

ORDレコード
ord-116adac64a8a438e812a14abc08bb7f8
出典データセット
uspto-grants-1995_07
特許番号
US05436224

反応ノート

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