Anthranilamide → HCID 722983、化合物

HRID 1648213ノート

反応式

HRID 1648213 の反応式
[C:1]([NH2:10])(=[O:9])[C:2]1[C:3](=[CH:5][CH:6]=[CH:7][CH:8]=1)[NH2:4].C(N(CC)CC)C.Cl.[C:19](Cl)(=[O:26])[C:20]1[CH:25]=[CH:24][CH:23]=[N:22][CH:21]=1>O1CCCC1.C(Cl)Cl>[N:22]1[CH:23]=[CH:24][CH:25]=[C:20]([C:19]([NH:4][C:3]2[CH:5]=[CH:6][CH:7]=[CH:8][C:2]=2[C:1]([NH2:10])=[O:9])=[O:26])[CH:21]=1

参加物

5

反応物 3

HCID 6942AnthranilamideHCID 8471TriethylamineHCID 884383-Pyridinecarbonyl chloride, hydrochloride (1:1)

生成物 1

HCID 722983HCID 722983、化合物収率 79.1%

試薬・触媒・溶媒 1

HCID 21919333Tetrahydrofurane dichloromethane溶媒

実験手順

To a solution of anthranilamide (8.2 g, being on sale) and triethylamine (18.0 g)in 100 mL of tetrahydrofuran/methylene chloride (1:1), was added nicotinoyl chloride hydrochloride (10.8 g). The mixture was allowed to stir at room temperature, under nitrogen atmosphere, for six hours. The solution was then concentrated under reduced pressure. The concentrate was taken up in ethyl acetate and water and the mixture filtered. The solid material was triturated in ether and filtered to give the title compound (11.5 g) as a yellow powder having the following physical data.

後処理

  1. concentrationThe solution was then concentrated under reduced pressure
  2. filtrationwater and the mixture filtered
  3. customThe solid material was triturated in ether
  4. filtrationfiltered

出典と根拠

ORDレコード
ord-43fef8841a4c4572974097215f443c08
出典データセット
uspto-grants-1995_07
特許番号
US05436233

反応ノート

読み込み中…