Formic Acid → 5-Methoxy-4-methylbenzimidazole

HRID 1648292ノート

反応式

HRID 1648292 の反応式
[CH3:1][O:2][C:3]1[C:4]([CH3:11])=[C:5]([NH2:10])[C:6]([NH2:9])=[CH:7][CH:8]=1.[CH:12](O)=O>>[CH3:1][O:2][C:3]1[CH:8]=[CH:7][C:6]2[NH:9][CH:12]=[N:10][C:5]=2[C:4]=1[CH3:11]

参加物

3

反応物 2

HCID 284Formic AcidHCID 5924544-Methoxy-3-methylbenzene-1,2-diamine

生成物 1

HCID 199193885-Methoxy-4-methylbenzimidazole収率 84%

反応条件

温度
60 °C

実験手順

A mixture of 4-methoxy-3-methyl-l,2-benzenediamine (2.8 g, 18A mmol) and formic acid (30 mL) was heated at 60° C. for 30 minutes. The formic acid was removed under reduced pressure and the product was partitioned between chloroform and water containing sufficient sodium hydroxide to basify the solution. After evaporation of the solvent the crude product was chromatographed (methanol:chloroform) to give 2.55 g (84%) of 5-methoxy-4-methyl-1H-benzimidazole.

後処理

  1. customThe formic acid was removed under reduced pressure
  2. customthe product was partitioned between chloroform and water containing sufficient sodium hydroxide
  3. customAfter evaporation of the solvent the crude product
  4. customwas chromatographed (methanol:chloroform)

出典と根拠

ORDレコード
ord-6be311e07a5947c88132b29c86c14593
出典データセット
uspto-grants-1995_07
特許番号
US05436240

反応ノート

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