1-Butanol → Allantoin

HRID 1648332

反応式

HRID 1648332 の反応式
[NH2:1][C:2]([NH2:4])=[O:3].S(=O)(=O)(O)O.[CH2:10]([OH:14])[CH2:11]CC>>[CH:11]1([NH:1][C:2]([NH2:4])=[O:3])[NH:4][C:2](=[O:3])[NH:1][C:10]1=[O:14]

参加物

4

反応物 3

HCID 2631-ButanolHCID 1118Sulfuric AcidHCID 1176Urea

生成物 1

HCID 204Allantoin

反応条件

温度
85 °C

実験手順

A mixture of 30.6 g of glyoxylic acid butyl ester butyl hemiacetal (0.15 mol), 30.0 g of urea (0.5 mol), 300 g of n-butanol and 7.5 g of 8% strength butanolic sulfuric acid was heated at 85° C. for a total of 4 hours. After the reaction had ended, the suspension formed was cooled to room temperature, whereupon a colorless precipitate separated out, which was filtered off, washed with methanol and dried in vacuo at 75° C. 23.1 g, that is to say 66% of theory, of crystalline allantoin acid butyl ester were obtained by this reaction.

後処理

  1. customthe suspension formed
  2. temperaturewas cooled to room temperature, whereupon a colorless precipitate
  3. customseparated out
  4. filtrationwhich was filtered off
  5. washwashed with methanol
  6. customdried in vacuo at 75° C

出典と根拠

ORDレコード
ord-09e0679c4a0148629a62a5e8c3e49e05
出典データセット
uspto-grants-1995_07
特許番号
US05436256

関連ノート

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