Diethylamine → 1,1-Di(phosphonic acid diethyl ester)-1-hydroxy ethane

HRID 1648466

反応式

HRID 1648466 の反応式
[P:1]([OH:8])([O:5][CH2:6][CH3:7])[O:2][CH2:3][CH3:4].C(NCC)C.[C:14]([P:17](=[O:24])([O:21][CH2:22][CH3:23])[O:18][CH2:19][CH3:20])(=[O:16])[CH3:15]>>[CH2:3]([O:2][P:1]([C:14]([P:17](=[O:24])([O:18][CH2:19][CH3:20])[O:21][CH2:22][CH3:23])([OH:16])[CH3:15])(=[O:8])[O:5][CH2:6][CH3:7])[CH3:4]

参加物

4

反応物 3

HCID 8021DiethylamineHCID 12977Ethyl phosphite, (C2H5O)2(OH)PHCID 522997Diethyl acetylphosphonate

生成物 1

HCID 5197731,1-Di(phosphonic acid diethyl ester)-1-hydroxy ethane

実験手順

Diethyl hydrogen phosphite (1.0 mole) and diethyl amine (1.0 mole) were combined in a round bottom flask. Diethyl acetylphosphonate (1.0 mole) was added dropwise, with stirring. The reaction mixture was maintained at a temperature of about 75° C. for an additional 2 hours after all of the diethyl acetyl phosphonate was added. The resulting mixture was distilled under reduced pressure to yield tetraethyl 1-hydroxyethylidene bisphosphonic acid as a pale yellowish liquid which crystallized at -15° C. into small needle-shaped crystals.

後処理

  1. additionwas added
  2. distillationThe resulting mixture was distilled under reduced pressure

出典と根拠

ORDレコード
ord-180bfe588f194ba8b35ebb3e4733a968
出典データセット
uspto-grants-1995_07
特許番号
US05436291

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