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Ethylene Glycol → trans-1-Benzoyl-3-bromo-4-(2-hydroxyethoxy)-pyrrolidine
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Ethylene Glycol | HCID 174 | — |
| 反応物 | Water | HCID 962 | — |
| 反応物 | N-bromobutanimide | HCID 67184 | — |
| 反応物 | 1H-Pyrrole, 1-benzoyl-2,5-dihydro- | HCID 11252283 | — |
| 生成物 | trans-1-Benzoyl-3-bromo-4-(2-hydroxyethoxy)-pyrrolidine | HCID 67598706 | — |
反応手順
95 g (0.55 mol) of 1-benzoyl-3-pyrroline are dissolved in 380 g of ethylene glycol, and 101 g (0.57 mol) of N-bromosuccinimide are added in 5 g portions over a period of 2 hours at room temperature. The mixture is then stirred overnight at room temperature and poured into water, followed by extraction with methylene chloride, drying over magnesium sulphate and concentration of the solution. The residue (188 g) was chromatographed with ethyl acetate on silica gel.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US05436334 |
| 出典データセット | uspto-grants-1995_07 |
| ORD ID | ord-099060e53aa9435c9af0c2e09017c8a9 |
| 出典メモ | uspto-grants-1995_07 |