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Chlorodiphenylmethane → Methyl Z-4-[[5-[[3-[(1,1'-biphenyl)-4-ylmethyl]-1-butyl-2,5-dioxo-4-imidazolidinylidene]methyl]-2-butyl-1H-imidazol-1-yl]methyl]benzoate

HRID 1648527
ノート
印刷プレビュー

反応式

HRID 1648527 の反応式
[CH2:1]([C:5]1[N:6]([CH2:22][C:23]2[CH:32]=[CH:31][C:26]([C:27]([O:29][CH3:30])=[O:28])=[CH:25][CH:24]=2)[C:7](/[CH:10]=[C:11]2\[NH:12][C:13](=[O:21])[N:14]([CH2:17][CH2:18][CH2:19][CH3:20])[C:15]\2=[O:16])=[CH:8][N:9]=1)[CH2:2][CH2:3][CH3:4].[C:33]([O-])([O-])=O.[K+].[K+].[C:39]1([CH:45](Cl)[C:46]2[CH:51]=[CH:50][CH:49]=[CH:48][CH:47]=2)[CH:44]=[CH:43][CH:42]=[CH:41]C=1>CN(C=O)C>[C:46]1([C:45]2[CH:41]=[CH:42][CH:43]=[CH:44][CH:39]=2)[CH:47]=[CH:48][C:49]([CH2:33][N:12]2[C:13](=[O:21])[N:14]([CH2:17][CH2:18][CH2:19][CH3:20])[C:15](=[O:16])/[C:11]/2=[CH:10]/[C:7]2[N:6]([CH2:22][C:23]3[CH:32]=[CH:31][C:26]([C:27]([O:29][CH3:30])=[O:28])=[CH:25][CH:24]=3)[C:5]([CH2:1][CH2:2][CH2:3][CH3:4])=[N:9][CH:8]=2)=[CH:50][CH:51]=1
参加物実験手順後処理出典と根拠反応ノート

参加物

5

反応物 3

HCID 7035ChlorodiphenylmethaneHCID 11430Potassium CarbonateHCID 11743857Methyl Z-4-[[2-butyl-5-[(1-butyl-2,5-dioxo-4-imidazolidinylidene)methyl]-1H-imidazol-1-yl]methyl]benzoate

生成物 1

HCID 19919870Methyl Z-4-[[5-[[3-[(1,1'-biphenyl)-4-ylmethyl]-1-butyl-2,5-dioxo-4-imidazolidinylidene]methyl]-2-butyl-1H-imidazol-1-yl]methyl]benzoate

試薬・触媒・溶媒 1

HCID 6228
Dimethylformamide
溶媒

実験手順

To a solution of methyl Z-4-[[2-butyl-5-[[1-butyl-2,5-dioxo-4-imidazolidinylidene]methyl]-1H-imidazol-1-yl]methyl]benzoate (0.438 g, 1.00 mmol) in DMF (10 mL) is added K2CO3 (0.42 g, 3.00 mmol). After stirring for 5 minutes diphenylmethyl chloride (0.210 g, 1.00 mmol) is added. The mixture is stirred for 16 hours, filtered, and evaporated in vacuo. The gum is dissolved in ethyl acetate and washed with water, brine and dried over MgSO4. Chromatography eluting with (50-100)% ethyl acetate in hexane, evaporation in vacuo affords a foam.

後処理

  1. additionis added
  2. filtrationfiltered
  3. customevaporated in vacuo
  4. dissolutionThe gum is dissolved in ethyl acetate
  5. washwashed with water, brine
  6. dry with materialdried over MgSO4
  7. washChromatography eluting with (50-100)% ethyl acetate in hexane, evaporation in vacuo
  8. customaffords a foam

出典と根拠

ORDレコード
ord-8d0ed006c2be4f96ad1fd3b6d5e76836
出典データセット
uspto-grants-1995_07
DOI
10.6084/m9.figshare.5104873.v1
特許番号
US05436260

反応ノート

読み込み中…

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