Imidazole → HCID 13269112、化合物

HRID 1648750ノート

反応式

HRID 1648750 の反応式
[Cl:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[CH:8]1[O:17][CH:9]1[C:10]1[CH:15]=[CH:14][CH:13]=[CH:12][C:11]=1[Cl:16].[NH:18]1[CH:22]=[CH:21][N:20]=[CH:19]1>O>[OH:17][CH:8]([C:3]1[CH:4]=[CH:5][CH:6]=[CH:7][C:2]=1[Cl:1])[CH:9]([N:18]1[CH:22]=[CH:21][N:20]=[CH:19]1)[C:10]1[CH:15]=[CH:14][CH:13]=[CH:12][C:11]=1[Cl:16]

参加物

4

反応物 2

HCID 795ImidazoleHCID 3009192,3-Bis(2-chlorophenyl)oxirane

生成物 1

HCID 13269112HCID 13269112、化合物収率 86.8%

試薬・触媒・溶媒 1

HCID 962Water溶媒

実験手順

A mixture of 11 g (0.04 m) of 2,2'-dichloro-α,α'-epoxybibenzyl and 15 g (0.22 m) of imidazole is heated at 160° for 11/2 hours. The reaction is cooled, diluted with water, and extracted with ether. The combined ether extracts are washed with water, then saturated sodium chloride solution, and dried over MgSO4. Solvent is evaporated to give 12 g of a gummy solid, mp 62°-68°.

後処理

  1. temperatureis heated at 160° for 11/2 hours
  2. temperatureThe reaction is cooled
  3. extractionextracted with ether
  4. washThe combined ether extracts are washed with water
  5. dry with materialsaturated sodium chloride solution, and dried over MgSO4
  6. customSolvent is evaporated

出典と根拠

ORDレコード
ord-fc1e1e8f49d54d999cc857014546529a
出典データセット
uspto-grants-1983_11
特許番号
US04413003

反応ノート

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