Imidazole → 1-[2-Hydroxy-2-(2,4-dichlorophenyl)hexyl]imidazole

HRID 1648752ノート

反応式

HRID 1648752 の反応式
Cl[CH2:2][C:3]([C:9]1[CH:14]=[CH:13][C:12]([Cl:15])=[CH:11][C:10]=1[Cl:16])([OH:8])[CH2:4][CH2:5][CH2:6][CH3:7].[NH:17]1[CH:21]=[CH:20][N:19]=[CH:18]1.O>CN(C)C=O>[OH:8][C:3]([C:9]1[CH:14]=[CH:13][C:12]([Cl:15])=[CH:11][C:10]=1[Cl:16])([CH2:4][CH2:5][CH2:6][CH3:7])[CH2:2][N:17]1[CH:21]=[CH:20][N:19]=[CH:18]1

参加物

5

反応物 3

HCID 795ImidazoleHCID 962WaterHCID 132368981-Chloro-2-(2,4-dichlorophenyl)hexan-2-ol

生成物 1

HCID 130588771-[2-Hydroxy-2-(2,4-dichlorophenyl)hexyl]imidazole収率 94.4%

試薬・触媒・溶媒 1

HCID 6228Dimethylformamide溶媒

実験手順

A mixture of 40 g (0.14 m) of 1-chloro-2-(2,4-dichlorophenyl)hexan-2-ol and 38.6 g (0.57 m) of imidazole in 10 ml of dimethyl formamide is heated at 160° for one hour. The reaction mixture is cooled, poured into 300 ml of water and extracted with ether. The combined ether extracts are washed with water, then saturated sodium chloride solution and dried over MgSO4. Solvent is evaporated to give 42 g of a gummy brown solid, mp 78°-80°.

後処理

  1. temperatureis heated at 160° for one hour
  2. temperatureThe reaction mixture is cooled
  3. extractionextracted with ether
  4. washThe combined ether extracts are washed with water
  5. dry with materialsaturated sodium chloride solution and dried over MgSO4
  6. customSolvent is evaporated

出典と根拠

ORDレコード
ord-399e614dc4124a21952f9b8e4eb1c762
出典データセット
uspto-grants-1983_11
特許番号
US04413003

反応ノート

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