Methyl Isocyanate → HCID 13228806、化合物

HRID 1648764ノート

反応式

HRID 1648764 の反応式
[C:1]([NH:5][OH:6])(=[O:4])[CH2:2][CH3:3].[CH3:7][N:8]=[C:9]=[O:10]>C(N(CC)CC)C.C(Cl)Cl>[CH3:7][NH:8][C:9]([N:5]([O:6][C:9]([NH:8][CH3:7])=[O:10])[C:1](=[O:4])[CH2:2][CH3:3])=[O:10]

参加物

5

反応物 2

HCID 12228Methyl IsocyanateHCID 75743N-Hydroxypropanamide

生成物 1

HCID 13228806HCID 13228806、化合物

試薬・触媒・溶媒 2

HCID 8471Triethylamine触媒HCID 6344Dichloromethane溶媒

実験手順

Propiohydroxamic acid (4.5 grams), methyl isocyanate (6.0 grams), and a few drops of triethylamine were stirred for about one hour in about 50 ml of methylene chloride. The resulting solution was allowed to stand at room temperature for about 48 hours, after which the solvent was removed by evaporation leaving a residue. The residue was recrystallized from a mixture of methylene chloride and hexane leaving the desired, N-((methylamino)carbonyl)-N-(((methylamino)carbonyl)-oxy)propionamide as white crystals, m.p. 90.5°-92.5° C.

後処理

  1. customafter which the solvent was removed by evaporation
  2. customleaving a residue
  3. customThe residue was recrystallized from a mixture of methylene chloride and hexane leaving the

出典と根拠

ORDレコード
ord-1849293a7a1545c9abd3053cf99f1cbd
出典データセット
uspto-grants-1983_11
特許番号
US04413009

反応ノート

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