Ethyl isocyanate → N-(Ethylcarbamoyl)-N-[(ethylcarbamoyl)oxy]propanamide

HRID 1648765ノート

反応式

HRID 1648765 の反応式
[C:1]([NH:5][OH:6])(=[O:4])[CH2:2][CH3:3].[CH2:7]([N:9]=[C:10]=[O:11])[CH3:8]>C(N(CC)CC)C.C(Cl)Cl>[CH2:7]([NH:9][C:10]([N:5]([O:6][C:10]([NH:9][CH2:7][CH3:8])=[O:11])[C:1](=[O:4])[CH2:2][CH3:3])=[O:11])[CH3:8]

参加物

5

反応物 2

HCID 8022Ethyl isocyanateHCID 75743N-Hydroxypropanamide

生成物 1

HCID 13228807N-(Ethylcarbamoyl)-N-[(ethylcarbamoyl)oxy]propanamide

試薬・触媒・溶媒 2

HCID 8471Triethylamine触媒HCID 6344Dichloromethane溶媒

実験手順

Propiohydroxamic acid (4.5 grams), ethyl isocyanate (8.0 grams), and a few drops of triethylamine were added to 100 ml of methylene chloride and allowed to stand at room temperature for about 12 hours. The solvent was then removed under vacuum leaving a residue which was recrystallized from a solution of methylene chloride and hexane leaving the desired, N-((ethylamino)carbonyl)-N-(((ethylamino)carbonyl)oxy)propionamide as white crystals, m.p. 104°-106° C.

後処理

  1. customThe solvent was then removed under vacuum
  2. customleaving a residue which
  3. customwas recrystallized from a solution of methylene chloride and hexane leaving the

出典と根拠

ORDレコード
ord-927f6c10ae484f9babd8e38cfc30aa76
出典データセット
uspto-grants-1983_11
特許番号
US04413009

反応ノート

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