Benzylamine → Diethyl 3-benzylamino-2-pentenedioate

HRID 1648839

反応式

HRID 1648839 の反応式
[CH2:1]([NH2:8])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[CH3:9][CH2:10][O:11][C:12]([CH2:14][C:15]([CH2:17][C:18]([O:20][CH2:21][CH3:22])=[O:19])=O)=[O:13]>C1(C)C=CC=CC=1>[CH2:10]([O:11][C:12](=[O:13])[CH:14]=[C:15]([NH:8][CH2:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1)[CH2:17][C:18]([O:20][CH2:21][CH3:22])=[O:19])[CH3:9]

参加物

4

反応物 2

HCID 7504BenzylamineHCID 66045Diethyl acetonedicarboxylate

生成物 1

HCID 70353029Diethyl 3-benzylamino-2-pentenedioate

試薬・触媒・溶媒 1

HCID 1140Toluene溶媒

実験手順

Benzylamine (89.1 g, 0.83 moles) is added over 10 minutes to a suspension of 5 A powdered molecular sieves (270 g) and diethyl 1,3-acetonedicarboxylate (160 g) (0.79 moles) in 350 ml toluene (external cooling applied to control exotherm). The suspension is stirred at room temperature for 14-17 hours and then filtered to provide 2. The filter cake is washed with three portions of toluene. The combined filtrates may be used as is in the subsequent ketene reaction.

後処理

  1. filtrationfiltered
  2. customto provide 2
  3. washThe filter cake is washed with three portions of toluene
  4. customas is in the subsequent ketene reaction

出典と根拠

ORDレコード
ord-60cd7bad4e4345d5bee1ab3238574070
出典データセット
uspto-grants-1983_11
特許番号
US04414155

関連ノート

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