2-Methoxyaniline → Acetamide, N-(2-methoxyphenyl)-

HRID 1648957

反応式

HRID 1648957 の反応式
[CH3:1][O:2][C:3]1[C:4]([NH2:9])=[CH:5][CH:6]=[CH:7][CH:8]=1.[C:10](OC(=O)C)(=[O:12])[CH3:11]>>[CH3:11][C:10]([NH:9][C:4]1[C:3]([O:2][CH3:1])=[CH:8][CH:7]=[CH:6][CH:5]=1)=[O:12]

参加物

3

反応物 2

HCID 70002-MethoxyanilineHCID 7918Acetic Anhydride

生成物 1

HCID 7135Acetamide, N-(2-methoxyphenyl)-

反応条件

温度
45 °C

実験手順

To 100 ml of acetic anhydride was added dropwise with stirring 100 g (0.813 mole) of o-anisidine, the temperature rising to about 60° C. during addition. The reaction mixture was heated on a steam bath for 15 minutes, allowed to cool to 45° C. and was poured onto 500 g of crushed ice. The white solid that precipitated was collected, washed free of acid with water and air dried to give 100 g, m.p. 84°-86° C., of product.

後処理

  1. additionthe temperature rising to about 60° C. during addition
  2. temperatureThe reaction mixture was heated on a steam bath for 15 minutes
  3. customThe white solid that precipitated
  4. customwas collected
  5. washwashed free of acid with water and air
  6. customdried
  7. customto give 100 g, m.p. 84°-86° C.

出典と根拠

ORDレコード
ord-dd72855b9a824be39a73e3a9415ab444
出典データセット
uspto-grants-1983_11
特許番号
US04414320

関連ノート

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