Acetone → 8-Methoxy-6-nitro-3,4-dihydroquinolin-2(1H)-one
反応式
[N+:1]([C:4]1[CH:5]=[C:6]2[C:11](=[C:12]([OH:14])[CH:13]=1)[NH:10][C:9](=[O:15])[CH2:8][CH2:7]2)([O-:3])=[O:2].[C:16](=O)([O-])[O-].[K+].[K+].CC(C)=O.S(OC)(OC)(=O)=O>O>[N+:1]([C:4]1[CH:5]=[C:6]2[C:11](=[C:12]([O:14][CH3:16])[CH:13]=1)[NH:10][C:9](=[O:15])[CH2:8][CH2:7]2)([O-:3])=[O:2]参加物
6
実験手順
6-Nitro-8-hydroxy-3,4-dihydrocarbostyril (10 g) and potassium carbonate (13.3 g) were mixed with acetone (70 ml) and water (70 ml) and the mixture was refluxed with adding dropwise 12.1 g of dimethyl sulfate. After refluxing was continued for 4 hours, the reaction mixture was cooled, and crystals which precipitated were collected by filtration and washed with water to give 8.22 g of 6-nitro-8-methoxy-3,4-dihydrocarbostyril.
後処理
- temperaturethe mixture was refluxed
- temperatureAfter refluxing
- temperaturethe reaction mixture was cooled
- customcrystals which precipitated
- filtrationwere collected by filtration
- washwashed with water
出典と根拠
- ORDレコード
- ord-ce801d41c2ee4dc780258c800ebf7e7a
- 出典データセット
- uspto-grants-1983_11
- 特許番号
- US04414390
反応ノート
読み込み中…