8-Methoxy-6-nitro-3,4-dihydroquinolin-2(1H)-one → 6-Amino-8-methoxy-3,4-dihydrocarbostyril
反応式
[N+:1]([C:4]1[CH:5]=[C:6]2[C:11](=[C:12]([O:14][CH3:15])[CH:13]=1)[NH:10][C:9](=[O:16])[CH2:8][CH2:7]2)([O-])=O.[H][H]>C(O)C.[C].[Pd]>[NH2:1][C:4]1[CH:5]=[C:6]2[C:11](=[C:12]([O:14][CH3:15])[CH:13]=1)[NH:10][C:9](=[O:16])[CH2:8][CH2:7]2参加物
5
実験手順
6-Nitro-8-methoxy-3,4-dihydrocarbostyril (2 g) and 5% palladium-carbon (0.2 g) were added in ethanol (50 ml) and catalytic reduction was conducted at a hydrogen gas pressure of 3 kg/cm2 for 1 hour. Then, the reaction mixture was filtered and the filtrate was concentrated. The residue was recrystallized from benzene to give 1.7 g of 6-amino-8-methoxy-3,4-dihydrocarbostyril.
後処理
- filtrationThen, the reaction mixture was filtered
- concentrationthe filtrate was concentrated
- customThe residue was recrystallized from benzene
出典と根拠
- ORDレコード
- ord-3ea3c1d9c82b40eba481b1683f89d792
- 出典データセット
- uspto-grants-1983_11
- 特許番号
- US04414390
反応ノート
読み込み中…