2-Chloroaniline → 1-(2-Chlorophenyl)pyrrolidin-2-one
反応式
[Cl:1][C:2]1[CH:8]=[CH:7][CH:6]=[CH:5][C:3]=1[NH2:4].[C:9]1(=O)[O:13][CH2:12][CH2:11][CH2:10]1>>[Cl:1][C:2]1[CH:8]=[CH:7][CH:6]=[CH:5][C:3]=1[N:4]1[CH2:9][CH2:10][CH2:11][C:12]1=[O:13]参加物
3
実験手順
Following example 19, 12.57 g (0.1 M) of 2-chloroaniline and 9.5 g (0.11 M) of γ-butyrolactone were heated for 48 hours. The excess starging materials were removed at 50°-80°/0.3 mm. Distillation of the residue gave 4.9 g (25%) of product (45% based on recovered 2-chloroaniline); b.p. 150°-155°/0.3-0.4 mm.
後処理
- temperaturewere heated for 48 hours
- customThe excess starging materials were removed at 50°-80°/0.3 mm
- distillationDistillation of the residue
出典と根拠
- ORDレコード
- ord-3af5252e9b2249d5a5f62a9761ecde0c
- 出典データセット
- uspto-grants-1983_11
- 特許番号
- US04415563
反応ノート
読み込み中…