Primaquine Diphosphate → Primaquine

HRID 1649351

反応式

HRID 1649351 の反応式
[CH3:1][CH:2]([NH:7][C:8]1[CH:13]=[C:12]([O:14][CH3:15])[CH:11]=[C:10]2[CH:16]=[CH:17][CH:18]=[N:19][C:9]=12)[CH2:3][CH2:4][CH2:5][NH2:6].OP(O)(O)=O.OP(O)(O)=O.CCCCCCCCCCCCCC(NCC(NC(CCCCCCCCCCCCC)=O)COP(OCC[N+](C)(C)C)([O-])=O)=O>>[CH3:1][CH:2]([NH:7][C:8]1[C:9]2[N:19]=[CH:18][CH:17]=[CH:16][C:10]=2[CH:11]=[C:12]([O:14][CH3:15])[CH:13]=1)[CH2:3][CH2:4][CH2:5][NH2:6]

参加物

3

反応物 2

HCID 6135Primaquine DiphosphateHCID 1309691,2-Dimyristoylamido-1,2-deoxyphosphatidylcholine

生成物 1

HCID 4908Primaquine

実験手順

Primaquine diphosphate solution was used for swelling DDPC/Ch/DCP mixture into liposomes, and the resulting liposomes were washed by centrifugation, and then suspended in a volume of saline four times of that used in swelling the vesicles. The concentration of drug was equivalent to 25 mg/kg primaquine diphosphate for 35 g mice when 0.1 ml was injected, or 376 mg/kg for 0.15 ml, or 50 mg/kg for 0.2 ml.

後処理

  1. washthe resulting liposomes were washed by centrifugation

出典と根拠

ORDレコード
ord-b3a6c3f5f81e45fc8f5b779079ba29ad
出典データセット
uspto-grants-1983_11
特許番号
US04416872

関連ノート

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