化工社化工社 化学情報印刷レポート · 研究参考用
Sodium Acetate → 1-(2-Aminothiazol-4-yl)-1-propencarboxylic acid ethyl ester
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Sodium Acetate | HCID 517045 | — |
| 反応物 | Thiourea | HCID 2723790 | — |
| 反応物 | Ethyl 2-ethylidene-4-chloro-3-oxobutyrate | HCID 54518096 | — |
| 溶媒 | Water | HCID 962 | — |
| 溶媒 | Tetrahydrofuran | HCID 8028 | — |
| 生成物 | 1-(2-Aminothiazol-4-yl)-1-propencarboxylic acid ethyl ester | HCID 54404371 | — |
反応手順
to a solution of 190 g of the product of example 81 in 400 ml tetrahydrofuran were added first a solution of 82 g sodium acetate in 150 ml of water and then 76 g thiourea. The solution was stirred at room temperature for 20 hours, then the THF was distilled off and acetic acid ethyl ester was added to the residue.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US04416880 |
| 出典データセット | uspto-grants-1983_11 |
| ORD ID | ord-9b4705d37edf4c80b2ad9f87b172ad31 |
| 出典メモ | uspto-grants-1983_11 |