Diethyl Ether → 2-Methylbenzonitrile
反応式
[CH:1]1([CH2:7][CH:8]2CCCC[N:9]2CC(C2C=CC=C(Br)C=2)C)CCC[CH2:3][CH2:2]1.[CH2:24]([Li])CCC.C(O[CH2:32][CH3:33])C>>[CH3:24][C:33]1[CH:32]=[CH:3][CH:2]=[CH:1][C:7]=1[C:8]#[N:9]参加物
4
実験手順
Following a procedure similar to that described in Example 7, 18.9 g. (0.05 mole) of 2-cyclohexylmethyl-1-[2-(3-bromophenyl)propyl]piperidine was reacted with 0.095 mole of n-butyl lithium in diethyl ether and the resulting lithio derivative reacted directly with 12.4 g. (0.106 mole) of 2-methylbenzonitrile to give 4.85 g. of 2-cyclohexylmethyl-1-{2-[3-(2-methylbenzoyl)phenyl]propyl}piperidine as a yellow oil.
出典と根拠
- ORDレコード
- ord-f5f30022c18d44809425d55c8e5fb026
- 出典データセット
- uspto-grants-1983_11
- 特許番号
- US04417052
反応ノート
読み込み中…