Sodium Bicarbonate → Ethyl 2,4-difluoro-3-amino-2-butenoate

HRID 1649555ノート

反応式

HRID 1649555 の反応式
[F:1][CH:2]([C:8](=O)[CH2:9][F:10])[C:3]([O:5][CH2:6][CH3:7])=[O:4].C([O-])(=O)C.[NH4+:16].C(=O)(O)[O-].[Na+]>CO>[F:1][C:2](=[C:8]([NH2:16])[CH2:9][F:10])[C:3]([O:5][CH2:6][CH3:7])=[O:4]

参加物

5

反応物 3

HCID 516892Sodium BicarbonateHCID 517165Ammonium AcetateHCID 15207128Ethyl 2,4-difluoro-3-oxobutanoate

生成物 1

HCID 86020216Ethyl 2,4-difluoro-3-amino-2-butenoate収率 45.4%

試薬・触媒・溶媒 1

HCID 887Methanol溶媒

実験手順

A mixture of ethyl 2,4-difluoro-3-oxobutanoate (24.6 g, 0.148 mol), ammonium acetate (200 g, 2.6 mol) and anhydrous methanol (400 mL) is stirred at room temperature for 3 days. The solution is poured into a saturated aqueous solution of sodium bicarbonate (1L) and extracted four times with ether. The combined organic phases are washed with brine and dried over magnesium sulfate. The solvent is evaporated to yield ethyl 2,4-difluoro-3-amino-2-butenoate (11.1 g, 45%)

後処理

  1. extractionextracted four times with ether
  2. washThe combined organic phases are washed with brine
  3. dry with materialdried over magnesium sulfate
  4. customThe solvent is evaporated

出典と根拠

ORDレコード
ord-1431f428058743c0a055444f4d89764d
出典データセット
uspto-grants-1983_11
特許番号
US04418077

反応ノート

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