Imidazole → 6-(Imidazol-1-ylacetyl)-3,4-dihydrocarbostyril
反応式
Cl[CH2:2][C:3]([C:5]1[CH:6]=[C:7]2[C:12](=[CH:13][CH:14]=1)[NH:11][C:10](=[O:15])[CH2:9][CH2:8]2)=[O:4].[NH:16]1[CH:20]=[CH:19][N:18]=[CH:17]1>CN(C)C=O.O>[N:16]1([CH2:2][C:3]([C:5]2[CH:6]=[C:7]3[C:12](=[CH:13][CH:14]=2)[NH:11][C:10](=[O:15])[CH2:9][CH2:8]3)=[O:4])[CH:20]=[CH:19][N:18]=[CH:17]1参加物
5
実験手順
A solution of 9.0 g of 6-(chloroacetyl)-3,4-dihydrocarbostyril and 13.4 g of imidazole in 40 ml of N,N-dimethylformamide was heated at 80° C. for 18 hours. The reaction mixture was diluted with 1000 ml of water and the precipitate filtered off, washed with water followed by a little acetone and dried under vacuum to afford 6-[(imidazol-1-yl)acetyl]-3,4-dihydrocarbostyril, having a melting point of 269°-273° C.
後処理
- filtrationthe precipitate filtered off
- washwashed with water
- customdried under vacuum
出典と根拠
- ORDレコード
- ord-2e92f9d25ec4494eb9611dc8fd86a8b1
- 出典データセット
- uspto-grants-1990_05
- 特許番号
- US04921862
反応ノート
読み込み中…