Triethylamine → HCID 14280741、化合物

HRID 1649777ノート

反応式

HRID 1649777 の反応式
[CH:1]1[C:10]2[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=2)[CH:4]=[CH:3][C:2]=1[CH:11](O)[CH2:12][N:13]([CH2:16][CH3:17])[CH2:14][CH3:15].C(N(CC)CC)C.CS([Cl:30])(=O)=O.[F:31][C:32]1[CH:45]=[CH:44][C:35]([C:36]([CH:38]2[CH2:43][CH2:42][NH:41][CH2:40][CH2:39]2)=[O:37])=[CH:34][CH:33]=1>ClCCl.O1CCOCC1>[ClH:30].[CH:1]1[C:10]2[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=2)[CH:4]=[CH:3][C:2]=1[CH:11]([N:41]1[CH2:42][CH2:43][CH:38]([C:36](=[O:37])[C:35]2[CH:34]=[CH:33][C:32]([F:31])=[CH:45][CH:44]=2)[CH2:39][CH2:40]1)[CH2:12][N:13]([CH2:16][CH3:17])[CH2:14][CH3:15]

参加物

7

反応物 4

HCID 8471TriethylamineHCID 31297Methanesulfonyl chlorideHCID 407267HCID 407267、化合物HCID 27244404-(4-Fluorobenzoyl)piperidine

生成物 1

HCID 14280741HCID 14280741、化合物

試薬・触媒・溶媒 2

HCID 6344Dichloromethane溶媒HCID 312751,4-Dioxane溶媒

実験手順

1.4 g of 1-(2-naphthyl)-2-diethylaminoethanol was dissolved in 20 ml of dichloromethane. 2.4 ml of triethylamine and 0.9 ml of methanesulfonyl chloride were added to the solution under cooling with ice and the mixture was stirred at room temperature for 4.5 h. A solution of 1.2 g of 4-(p-fluorobenzoyl)piperidine in 25 ml of dioxane was added to the reaction mixture and the obtained mixture was refluxed for 2 h. After completion of the reaction, the product was purified according to silica gel column chromatography and then converted into its hydrochloride.

後処理

  1. temperatureunder cooling with ice
  2. temperaturethe obtained mixture was refluxed for 2 h
  3. customAfter completion of the reaction
  4. customthe product was purified

出典と根拠

ORDレコード
ord-343a84def31d43f6be2ecd17683f8e60
出典データセット
uspto-grants-1990_05
特許番号
US04921863

反応ノート

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