2-[6-[(6-Bromohexyl)oxy]-1-hexynyl]-4-pyridinecarboxamide → 2-[6-[(6-Bromohexyl)oxy]hexyl]-4-pyridinecarboxamide
反応式
[Br:1][CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][O:8][CH2:9][CH2:10][CH2:11][CH2:12][C:13]#[C:14][C:15]1[CH:20]=[C:19]([C:21]([NH2:23])=[O:22])[CH:18]=[CH:17][N:16]=1>C(O)C.[Pd]=O>[Br:1][CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][O:8][CH2:9][CH2:10][CH2:11][CH2:12][CH2:13][CH2:14][C:15]1[CH:20]=[C:19]([C:21]([NH2:23])=[O:22])[CH:18]=[CH:17][N:16]=1参加物
4
実験手順
A solution of 2-[6-[(6-bromohexyl)oxy]-1-hexynyl]-4-pyridinecarboxamide (1.04 g) in ethanol (20 ml) was hydrogenated over pre-hydrogenated 10% palladium oxide on carbon (50% aqueous paste, 115 mg). The mixture was filtered through hyflo and the filtrate evaporated to give the title compound as a pale yellow solid (1.05 g), m.p. 73°-75°.