Hydrochloric Acid → 6-Chloro-1-methyl-3-n-octyl-uracil

HRID 1650125ノート

反応式

HRID 1650125 の反応式
[CH2:1](Br)[CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][CH3:8].[Cl:10][C:11]1[N:16]([CH3:17])[C:15](=[O:18])[NH:14][C:13](=[O:19])[CH:12]=1.C(=O)([O-])[O-].[K+].[K+].Cl>O.CN(C)C=O>[Cl:10][C:11]1[N:16]([CH3:17])[C:15](=[O:18])[N:14]([CH2:1][CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][CH3:8])[C:13](=[O:19])[CH:12]=1

参加物

7

反応物 4

HCID 313Hydrochloric AcidHCID 81401-BromooctaneHCID 11430Potassium CarbonateHCID 3015589Uracil, 6-chloro-1-methyl-

生成物 1

HCID 230536246-Chloro-1-methyl-3-n-octyl-uracil

試薬・触媒・溶媒 2

HCID 962Water溶媒HCID 6228Dimethylformamide溶媒

反応条件

温度
90 °C

実験手順

Next 5.4 ml of n-octyl bromide was added to a solution consisting of 5 grams of 6-chloro-1-methyl-uracil obtained as described above, 5.2 grams of potassium carbonate and 50 ml of N,N-dimethylformamide and the mixture was heated to 90° C. and stirred for a period of 5 hours. After cooling, the reaction mixture was added slowly to a solution of 10 ml of concentrated hydrochloric acid and 300 ml of water. The resulting solution was extracted twice with 100 ml of chloroform and, after drying over magnesium sulfate, the chloroform layer was concentrated under reduced pressure. The concentrate was then refined using silica gel column chromatography, whereupon 3.1 grams of 6-chloro-1-methyl-3-n-octyl-uracil was obtained in the form of white crystals.

後処理

  1. customobtained
  2. temperatureAfter cooling
  3. extractionThe resulting solution was extracted twice with 100 ml of chloroform
  4. dry with materialafter drying over magnesium sulfate
  5. concentrationthe chloroform layer was concentrated under reduced pressure

出典と根拠

ORDレコード
ord-d2e62a0e53d043f4972f5250144a878a
出典データセット
uspto-grants-1990_05
特許番号
US04923789

反応ノート

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