HCID 23053854、化合物 → HCID 23053853、化合物

反応式

[Cl:1][C:2]1[CH:3]=[C:4]([C:10]([NH2:12])=[O:11])[CH:5]=[C:6]([Cl:9])[C:7]=1Cl.[K].[C:14]1([SH:24])[C:23]2[C:18](=[CH:19][CH:20]=[CH:21][CH:22]=2)[CH:17]=[CH:16][CH:15]=1>CN(C)C=O.O>[Cl:9][C:6]1[CH:5]=[C:4]([C:10]([NH2:12])=[O:11])[CH:3]=[C:2]([Cl:1])[C:7]=1[S:24][C:14]1[C:23]2[C:18](=[CH:19][CH:20]=[CH:21][CH:22]=2)[CH:17]=[CH:16][CH:15]=1

参加物

実験手順

To a solution of 3,4,5-trichlorobenzene carboxamide (25 g) in 220 ml of dry dimethylformamide (DMF), 26 g of 1-naphthalenethiol potassium salt is added and the reaction mixture stirred at room temperature for two days. The reaction mixture is then diluted with water and extracted with methylene chloride. The combined extracts are washed with water, dried with anhydrous magnesium sulfate and concentrated. The product can be purified by chromatography on silica gel.