Boron trifluoride etherate → Methyl 4-(mercaptomethyl)-1,3-dithiolane-2-propanoate

HRID 1650259ノート

反応式

HRID 1650259 の反応式
[SH:1][CH2:2][CH:3]([SH:6])[CH2:4][SH:5].O=[CH:8][CH2:9][CH2:10][C:11]([O:13][CH3:14])=[O:12].B(F)(F)F.CCOCC>C(Cl)Cl>[SH:1][CH2:2][CH:3]1[CH2:4][S:5][CH:8]([CH2:9][CH2:10][C:11]([O:13][CH3:14])=[O:12])[S:6]1

参加物

5

反応物 3

HCID 8000Boron trifluoride etherateHCID 784951,2,3-PropanetrithiolHCID 83779Methyl 4-oxobutyrate

生成物 1

HCID 14405952Methyl 4-(mercaptomethyl)-1,3-dithiolane-2-propanoate

試薬・触媒・溶媒 1

HCID 6344Dichloromethane溶媒

実験手順

The title compound was prepared according to the procedure of Example 1 using 1,2,3-trimercaptopropane (4.21 g, 0.03 mol), methyl 4-oxobutanoate from Example 73 (3.5 g, 0.03 mol) and boron trifluoride etherate (1 ml) in methylene chloride (75 ml). The crude product was chromatographed on silica gel using 5% ethyl acetate/hexane as eluent to give 2.5 g (35%) of product.

後処理

  1. customThe crude product was chromatographed on silica gel using 5% ethyl acetate/hexane as eluent

出典と根拠

ORDレコード
ord-bcf38bee78c748e2937ac3d15f6b3e59
出典データセット
uspto-grants-1990_05
特許番号
US04923891

反応ノート

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