3,5,5-Trimethyl-2-pyrazoline → 1-(2,6-Dichlorophenylsulphonylcarbamoyl)-3,5,5-trimethyl-2-pyrazoline

HRID 1650989ノート

反応式

HRID 1650989 の反応式
[CH3:1][C:2]1[CH2:6][C:5]([CH3:8])([CH3:7])[NH:4][N:3]=1.[Cl:9][C:10]1[CH:15]=[CH:14][CH:13]=[C:12]([Cl:16])[C:11]=1[S:17]([N:20]=[C:21]=[O:22])(=[O:19])=[O:18]>O.C1(C)C=CC=CC=1>[Cl:9][C:10]1[CH:15]=[CH:14][CH:13]=[C:12]([Cl:16])[C:11]=1[S:17]([NH:20][C:21]([N:4]1[C:5]([CH3:8])([CH3:7])[CH2:6][C:2]([CH3:1])=[N:3]1)=[O:22])(=[O:18])=[O:19]

参加物

5

反応物 2

HCID 2314643,5,5-Trimethyl-2-pyrazolineHCID 128751892,6-Dichlorobenzenesulfonyl isocyanate

生成物 1

HCID 230508981-(2,6-Dichlorophenylsulphonylcarbamoyl)-3,5,5-trimethyl-2-pyrazoline

試薬・触媒・溶媒 2

HCID 962Water溶媒HCID 1140Toluene溶媒

実験手順

11.2 g of the 3,5,5-trimethyl-2-pyrazoline obtained according to example I(b) are added dropwise while stirring, cooling in cold water and under a nitrogen blanket to a solution of 25.2 g of the 2,6-dichlorobenzenesulphonylisocyanate obtained according to example I(a) in 200 ml of dry toluene. After stirring at room temperature for two hours, the precipitate is sucked off and washed successively with dry toluene and petroleum ether (40-60). The desired 1-(2,6-dichlorophenylsulphonylcarbamoyl)-3,5,5-trimethyl-2-pyrazoline is obtained in a yield of 20.07 g; melting-point 270° C. (decomposition).

後処理

  1. additionare added dropwise
  2. customobtained
  3. stirringAfter stirring at room temperature for two hours
  4. washwashed successively with dry toluene and petroleum ether (40-60)

出典と根拠

ORDレコード
ord-cf3b4d36ab914790bb87113a3ce05a18
出典データセット
uspto-grants-1990_05
特許番号
US04927452

反応ノート

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