2-Pyrazoline → 1-(2,6-Difluorophenylsulphonylcarbamoyl)-2-pyrazoline

HRID 1650992

反応式

HRID 1650992 の反応式
[F:1][C:2]1[CH:7]=[CH:6][CH:5]=[C:4]([F:8])[C:3]=1[S:9]([NH:12][C:13]([NH2:15])=[O:14])(=[O:11])=[O:10].[NH:16]1[CH2:20][CH2:19][CH:18]=N1>O1CCOCC1>[F:1][C:2]1[CH:7]=[CH:6][CH:5]=[C:4]([F:8])[C:3]=1[S:9]([NH:12][C:13]([N:15]1[CH2:18][CH2:19][CH:20]=[N:16]1)=[O:14])(=[O:11])=[O:10]

参加物

4

反応物 2

HCID 669622-PyrazolineHCID 53937098N-(2,6-difluorophenylsulphonyl)urea

生成物 1

HCID 230507491-(2,6-Difluorophenylsulphonylcarbamoyl)-2-pyrazoline

試薬・触媒・溶媒 1

HCID 312751,4-Dioxane溶媒

実験手順

N-(2,6-difluorophenylsulphonyl)urea in an amount of 2.36 and 1.40 g of 2-pyrazoline in 20 ml of dioxane are refluxed for 4 hours. After evaporation of the solvent at reduced pressure, the remaining solid is dissolved in 20 ml of water. This solution is filtrated and acidified with conc. hydrochloric acid. The precipitate is sucked off, washed with water and dried, yielding the title product, viz. 1-(2,6-difluorophenylsulphonylcarbamoyl)-2-pyrazoline in a yield of 1.87 g; melting point 183° C.

後処理

  1. customAfter evaporation of the solvent at reduced pressure
  2. dissolutionthe remaining solid is dissolved in 20 ml of water
  3. filtrationThis solution is filtrated
  4. washwashed with water
  5. customdried

出典と根拠

ORDレコード
ord-b18fa86a7df846fa805fdd7829ec0e5a
出典データセット
uspto-grants-1990_05
特許番号
US04927452

関連ノート

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