Formic Acid → methyl N-formyl-N-(1,2,3,4,4a,9a-hexahydro-9H-fluoren-9-yl)glycine

HRID 1650994ノート

反応式

HRID 1650994 の反応式
[CH3:1][N:2]([CH:7]1[CH:19]2[CH:14]([CH2:15][CH2:16][CH2:17][CH2:18]2)[C:13]2[C:8]1=[CH:9][CH:10]=[CH:11][CH:12]=2)[CH2:3][C:4](O)=O.[CH:20]([OH:22])=[O:21].C(OC(=O)C)(=[O:25])C>O>[CH3:4][CH:3]([C:20]([OH:22])=[O:21])[N:2]([CH:1]=[O:25])[CH:7]1[CH:19]2[CH:14]([CH2:15][CH2:16][CH2:17][CH2:18]2)[C:13]2[C:8]1=[CH:9][CH:10]=[CH:11][CH:12]=2

参加物

5

反応物 3

HCID 284Formic AcidHCID 7918Acetic AnhydrideHCID 70360266methyl N-(1,2,3,4,4a,9a-hexahydro-9H-fluoren-9-yl)glycine

生成物 1

HCID 86743034methyl N-formyl-N-(1,2,3,4,4a,9a-hexahydro-9H-fluoren-9-yl)glycine収率 86.4%

試薬・触媒・溶媒 1

HCID 962Water溶媒

実験手順

A mixture of 16.6 parts of methyl N-(1,2,3,4,4a,9a-hexahydro-9H-fluoren-9-yl)glycine, 44 parts of formic acid and 11.9 parts of acetic acid anhydride was stirred overnight at room temperature. The reaction mixture was poured into water and the product was extracted with trichloromethane. The extract was dried, filtered and evaporated, yielding 15.9 parts (86.4%) of methyl N-formyl-N-(1,2,3,4,4a,9a-hexahydro-9H-fluoren-9-yl)glycine as a residue (int. 2).

後処理

  1. extractionthe product was extracted with trichloromethane
  2. customThe extract was dried
  3. filtrationfiltered
  4. customevaporated

出典と根拠

ORDレコード
ord-9c1e59c1489c4c82b0884af8a246c1a9
出典データセット
uspto-grants-1990_05
特許番号
US04927449

反応ノート

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