Hydrochloric Acid → 2-Methoxyimino-3-oxobutyric acid

HRID 1651334ノート

反応式

HRID 1651334 の反応式
[CH3:1][O:2][N:3]=[C:4]([C:12](=[O:14])[CH3:13])[C:5]([O:7]C(C)(C)C)=[O:6].Cl>C(Cl)Cl>[CH3:1][O:2][N:3]=[C:4]([C:12](=[O:14])[CH3:13])[C:5]([OH:7])=[O:6]

参加物

4

反応物 2

HCID 313Hydrochloric AcidHCID 54110352Tert-butyl 2-methoxyimino-3-oxobutyrate

生成物 1

HCID 541834952-Methoxyimino-3-oxobutyric acid収率 95.8%

試薬・触媒・溶媒 1

HCID 6344Dichloromethane溶媒

実験手順

Tertiary-butyl 2-methoxyimino-3-oxobutyrate (805 g) was dissolved in 2.8 liters of methylene chloride. Hydrogen chloride (210 g) was blown into the solution at 3° to 6° C. over 8 hours. Then, the resultant mixture was allowed to stand at 5° C. for 15 hours. The supernatant was concentrated to dryness to give 556 g of 2-methoxyimino-3-oxobutyric acid as a crystalline solid.

後処理

  1. concentrationThe supernatant was concentrated to dryness

出典と根拠

ORDレコード
ord-f754cb83fa5841ae83ec40d69a34540c
出典データセット
uspto-grants-1990_05
特許番号
US04927964

反応ノート

読み込み中…