Ammonium Hydroxide → Methyl 5-sulfamoylthieno[2,3-b]thiophene-2-carboxylate

HRID 1651509ノート

反応式

HRID 1651509 の反応式
[OH-].[NH4+:2].[CH3:3][O:4][C:5]([C:7]1[S:11][C:10]2[S:12][C:13]([S:15](Cl)(=[O:17])=[O:16])=[CH:14][C:9]=2[CH:8]=1)=[O:6]>CC(C)=O>[CH3:3][O:4][C:5]([C:7]1[S:11][C:10]2[S:12][C:13]([S:15]([NH2:2])(=[O:17])=[O:16])=[CH:14][C:9]=2[CH:8]=1)=[O:6]

参加物

4

反応物 2

HCID 14923Ammonium HydroxideHCID 14700201129949-97-9

生成物 1

HCID 14700202Methyl 5-sulfamoylthieno[2,3-b]thiophene-2-carboxylate

試薬・触媒・溶媒 1

HCID 180Acetone溶媒

実験手順

To stirred ammonium hydroxide (150 ml) was added dropwise 5-methoxycarbonylthieno[2,3-b]thiophene-2-sulfonyl chloride (11.58 g. 39.02 mmoles) dissolved in acetone (140 ml). After the addition was complete, the solution was stirred for 30 minutes. The reaction was worked up by evaporating the ammonia and acetone in vacuo. The crystals were collected and dried (9.66 g.) (89%). Recrystallization from nitromethane gave 7.02 g. mp 219°-220° C.

後処理

  1. additionAfter the addition
  2. customby evaporating the ammonia and acetone in vacuo
  3. customThe crystals were collected
  4. customdried (9.66 g.) (89%)
  5. customRecrystallization from nitromethane
  6. customgave 7.02 g

出典と根拠

ORDレコード
ord-dc46fc38822d48d4af7543855b3a61b2
出典データセット
uspto-grants-1990_05
特許番号
US04929549

反応ノート

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