1-Propanamine, 3-(2-methoxyethoxy)- → 5-(N-methoxyethoxypropylcarbamoyl)thieno[2,3-b]thiophene-2-sulfonamide

HRID 1651510ノート

反応式

HRID 1651510 の反応式
CO[C:3]([C:5]1[S:9][C:8]2[S:10][C:11]([S:13]([NH2:16])(=[O:15])=[O:14])=[CH:12][C:7]=2[CH:6]=1)=[O:4].[CH3:17][O:18][CH2:19][CH2:20][O:21][CH2:22][CH2:23][CH2:24][NH2:25]>CO>[CH3:17][O:18][CH2:19][CH2:20][O:21][CH2:22][CH2:23][CH2:24][NH:25][C:3]([C:5]1[S:9][C:8]2[S:10][C:11]([S:13]([NH2:16])(=[O:14])=[O:15])=[CH:12][C:7]=2[CH:6]=1)=[O:4]

参加物

4

反応物 2

HCID 1085741-Propanamine, 3-(2-methoxyethoxy)-HCID 14700202Methyl 5-sulfamoylthieno[2,3-b]thiophene-2-carboxylate

生成物 1

HCID 147002065-(N-methoxyethoxypropylcarbamoyl)thieno[2,3-b]thiophene-2-sulfonamide収率 64.7%

試薬・触媒・溶媒 1

HCID 887Methanol溶媒

実験手順

5-Methoxycarbonylthieno[2,3-b]thiophene-2-sulfonamide (0.55 g., 2 mmoles) and 3-(methoxyethoxy)propylamine (0.80 g., 6 mmoles) were refluxed in methanol (5 mL) for 96 hours. The solution was cooled and evaporated in vacuo to remove most of the methanol. Ether was added and the resulting product was recrystallized from 1,2-dichloroethane to give 0.49 g of 5-(N-methoxyethoxypropylcarbamoyl)thieno[2,3-b]thiophene-2-sulfonamide, m.p. 154°-155° C.

後処理

  1. temperatureThe solution was cooled
  2. customevaporated in vacuo
  3. customto remove most of the methanol
  4. additionEther was added
  5. customthe resulting product was recrystallized from 1,2-dichloroethane

出典と根拠

ORDレコード
ord-e735d9f296a140f5a9de6040ffef178b
出典データセット
uspto-grants-1990_05
特許番号
US04929549

反応ノート

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