Maleic Acid → HCID 67870636、化合物

HRID 1651562

反応式

HRID 1651562 の反応式
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([CH:8]([C:22]2[CH:27]=[CH:26][CH:25]=[CH:24][N:23]=2)[O:9][CH:10]2[CH2:15][CH2:14][N:13]([CH2:16][CH2:17][CH2:18][C:19]([NH2:21])=[O:20])[CH2:12][CH2:11]2)=[CH:4][CH:3]=1.[C:28]([OH:35])(=[O:34])/[CH:29]=[CH:30]\[C:31]([OH:33])=[O:32]>C(O)C>[C:28]([OH:35])(=[O:34])/[CH:29]=[CH:30]\[C:31]([OH:33])=[O:32].[Cl:1][C:2]1[CH:3]=[CH:4][C:5]([CH:8]([C:22]2[CH:27]=[CH:26][CH:25]=[CH:24][N:23]=2)[O:9][CH:10]2[CH2:15][CH2:14][N:13]([CH2:16][CH2:17][CH2:18][C:19]([NH2:21])=[O:20])[CH2:12][CH2:11]2)=[CH:6][CH:7]=1

参加物

4

反応物 2

HCID 444266Maleic AcidHCID 150558684-[4-[(4-Chlorophenyl)-2-pyridylmethoxy]-1-piperidyl]butanamide

生成物 1

HCID 67870636HCID 67870636、化合物収率 71%

試薬・触媒・溶媒 1

HCID 702Ethanol溶媒

実験手順

0.38 g (0.98 mmol) of the amide obtained in Example 29 was dissolved in 3 ml of ethanol, and 0.11 g (0.98 mmol) of maleic acid was added. The precipitated white crystals were recrystallized from ethyl acetate to give 0.35 g (71%) of 4-[4-[(4-chlorophenyl)-2-pyridylmethoxy]-1-piperidyl]butanamide maleate.

後処理

  1. customThe precipitated white crystals were recrystallized from ethyl acetate

出典と根拠

ORDレコード
ord-fc152e1eeda44418a9e073e48c92ddf4
出典データセット
uspto-grants-1990_05
特許番号
US04929618

関連ノート

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