Acetic Anhydride → HCID 86743970、化合物

HRID 1651581ノート

反応式

HRID 1651581 の反応式
[C:1]([NH:4][CH:5]1[CH2:9][CH2:8][CH:7]([C:10]2[C:15]([F:16])=[CH:14][C:13]([C:17](=[O:24])[CH2:18][C:19]([O:21][CH2:22][CH3:23])=[O:20])=[C:12]([F:25])[CH:11]=2)[CH2:6]1)(=[O:3])[CH3:2].[CH:26](OCC)(OCC)[O:27][CH2:28][CH3:29].C(OC(=O)C)(=O)C>>[C:1]([NH:4][CH:5]1[CH2:9][CH2:8][CH:7]([C:10]2[C:15]([F:16])=[CH:14][C:13]([C:17](=[O:24])[C:18](=[CH:26][O:27][CH2:28][CH3:29])[C:19]([O:21][CH2:22][CH3:23])=[O:20])=[C:12]([F:25])[CH:11]=2)[CH2:6]1)(=[O:3])[CH3:2]

参加物

4

反応物 3

HCID 7918Acetic AnhydrideHCID 31214Ethyl orthoformateHCID 14770849HCID 14770849、化合物

生成物 1

HCID 86743970HCID 86743970、化合物

実験手順

A solution of 17.7 g (50 mmol) of 4-[3-(acetylamino)cyclopentyl]-2,5-difluoro-β-oxobenzenepropanoic acid, ethyl ester, 11.1 g (75 mmol) triethyl orthoformate and 75 ml of acetic anhydride was refluxed for 3 hours. The solvent was removed in vacuo and the residue triturated with toluene which was also removed in vacuo, then in high vacuo at 50°. The residue, 20.1 g, was used without further purification.

後処理

  1. customThe solvent was removed in vacuo
  2. customthe residue triturated with toluene which
  3. customwas also removed in vacuo
  4. customat 50°
  5. customThe residue, 20.1 g, was used without further purification

出典と根拠

ORDレコード
ord-23fe9ec554094c6f81ecd160c56a9471
出典データセット
uspto-grants-1990_05
特許番号
US04929613

反応ノート

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